Michael E. Belloy, PhD, Stanford University, Stanford, CA, discusses his recent genome-wide associate study (GWAS), investigating how genetic variation between the biological sexes and APOE4 carriers versus non-carriers is related to late-onset Alzheimer’s disease (AD) risk. Genetic risk factors for AD differ depending on sex and the presence of the APOE4 allele. In this study, large scale genetic analysis was undertaken on publicly available data of individuals with an AD diagnosis or a family history of AD. GWAS was utilized to identify genetic risk loci differentially associated with AD risk across APOE4 and/or sex, and functional follow-up analyses assessed potential relevance to AD based on mechanistic links or QTL co-localization. This research overall hopes to uncover genes which may be therapeutic targets. This interview took place at the Alzheimer’s Association International Conference® (AAIC) 2023 in Amsterdam, Netherlands.
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