One key difference compared to the centiloid scale is that with tau PET, there are multiple regions in the brain that can be evaluated and that can be relevant. With the centiloid scale, we only had one large composite ROI that covered a significant portion of the cortex, right? Here, for tau, we have multiple regions of interest, right? And therefore, we need to derive a different conversion equation for each ROI...
One key difference compared to the centiloid scale is that with tau PET, there are multiple regions in the brain that can be evaluated and that can be relevant. With the centiloid scale, we only had one large composite ROI that covered a significant portion of the cortex, right? Here, for tau, we have multiple regions of interest, right? And therefore, we need to derive a different conversion equation for each ROI. Now, this can be considered a bit of a limitation, right? So what we are exploring now is whether we can apply a single conversion equation to the entire brain and still get good harmonization results. So this is what we tried to do in this study. But for now, yeah, the results are a bit unclear. It really seems like some regions in particular, the medial temporal lobe, the equation is a bit different compared to the equations you would get in the neocortex. So this is very preliminary. We ran a few experiments using the metatemporal conversion equation to the entire brain. The results look promising, but still, I think it’s still early to conclude that we can use just a single equation and achieve a good harmonization across all the radiotracers and pipelines.
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