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CTAD 2025 | Objectives of the LifeAfter90 study: understanding cognitive decline in the oldest-old

Batool Rizvi, PhD, University of California, Davis, CA, discusses the LifeAfter90 study, an ongoing longitudinal cohort study investigating life course factors of cognitive decline and brain imaging markers in individuals aged 90 years and older. Dr Rizvi highlights that the study aims to understand the contributions of neuroimaging markers on cognitive decline and Alzheimer’s disease, as well as identify life course predictors of successful aging in individuals with exceptional longevity. This interview took place at the 18th Clinical Trials on Alzheimer’s Disease (CTAD) Conference in San Diego, CA.

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Transcript

So hi, so my name is Batool and I wanted to talk about the Life After 90 study. So the Life After 90 is an ongoing longitudinal cohort study that investigates life course factors of cognitive decline and brain imaging markers in the oldest old or individuals aged 90 years and older. And the Life After 90 study is the largest, most ethnically and racially diverse cohort study of the oldest old with prospective clinical and lifestyle data as well...

So hi, so my name is Batool and I wanted to talk about the Life After 90 study. So the Life After 90 is an ongoing longitudinal cohort study that investigates life course factors of cognitive decline and brain imaging markers in the oldest old or individuals aged 90 years and older. And the Life After 90 study is the largest, most ethnically and racially diverse cohort study of the oldest old with prospective clinical and lifestyle data as well. And eligible participants are Spanish-speaking and/or English-speaking. They are long-term members of Kaiser Permanente, Northern California. And they also reside in the San Francisco Bay Area or Sacramento areas of California. So participants of the Life After 90 study are seen every six months. And these visits include an extensive neuropsychological battery, as well as a clinical exam. They also include research interviews and measures of life course social experience. And they are also asked to be part of the brain donation programs and a subset undergo PET and MRI neuroimaging. And some of the objectives of this ongoing study are to understand the contributions of neuroimaging markers of amyloid, vascular injury, as well as brain atrophy on cognitive decline and on Alzheimer’s disease and related dementias. And other objectives include to identify and to understand life course predictors of successful aging in those who are undergoing exceptional longevity.

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