Diane Chan, MD, PhD, Massachusetts Institute of Technology, Cambridge, MA, discusses our current understanding of the mechanisms underpinning the beneficial effects of gamma stimulation in Alzheimer’s disease (AD). Early studies suggest that 40Hz stimulation can elicit beneficial effects on brain function, disease pathology, and cognitive function in individuals with AD. Evidence from animal models indicates that boosting gamma power via audiovisual gamma frequency sensory may improve glymphatic flow, improving the removal of amyloid in the process. Microglia, astrocytes, and neurons are also thought to be impacted. The multi-faceted role of gamma oscillations for neuronal function must be further characterized. Dr Chan remarks on the prospect of using gamma frequency stimulation for other neurodegenerative pathologies, including Parkinson’s disease. This interview took place at the AD/PD™ 2024 congress in Lisbon, Portugal.
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