So that publication was a collaborative effort from the comorbidity and multimorbidity group in the Alzheimer’s Association that Dr Lucy Sterling from University of Edinburgh and I co-chaired for the last two years. And so this group had experts from around the world, who are working on the comorbidity space. The first manuscript talked about the clinical epidemiological prevalence of comorbidity and multimorbidity...
So that publication was a collaborative effort from the comorbidity and multimorbidity group in the Alzheimer’s Association that Dr Lucy Sterling from University of Edinburgh and I co-chaired for the last two years. And so this group had experts from around the world, who are working on the comorbidity space. The first manuscript talked about the clinical epidemiological prevalence of comorbidity and multimorbidity. And most of us know that people with Alzheimer’s don’t die of Alzheimer’s, they die of other complications like cardiac failure, renal problems, falls and fractures, as I mentioned earlier. So we felt the need to kind of bring us all together and look at the clinical relevance of these comorbidities. And we found that there are many large data sets around the world, large population studies, and we see increasing prevalence of the comorbid conditions as well as multiple conditions existing together when people age and when they have dementia. And as a next step, we want to further expand and then get into details of what are the comorbidity and multimorbidity that interplay in each of the particular organs. So we want to be able to look into detail about what are the mechanisms that are contributing to the common physiologies in the brain and the bone or heart and bone so that we can eventually probably find shared therapeutic targets. For example, follicle-stimulating hormone is one thing that we saw that is going up. So follicle-stimulating hormone, it contributes to bone loss as well as brain atrophy at the same time. And so once we are giving anti-FSH treatment, it can target, like it can improve brain health and bone health at the same time. Similarly, we want to identify shared therapeutic targets for all the different organs so that probably we can use fewer medications as well as to treat two coexisting conditions or even multiple coexisting conditions at the same time.
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