George Perry, PhD, University of Texas at San Antonio, San Antonio, TX, addresses the heterogeneity of Alzheimer’s disease (AD). With new terminology for varying stages of AD onset, researchers are beginning to think that perhaps these are variants of a similar condition – considering that AD may be more of a syndrome than a disease. Cascade hypotheses have been considered on the grounds for identifying the cause of AD; however, they have helped us understand the disease mechanisms rather than identify the cause. Dr Perry discusses that AD is most likely not caused by a single factor – with a two-hit hypothesis considering oxidative stress and cell cycle re-entry being the closest their work has come to a cascade hypothesis. There could be any combination of multiple factors contributing to AD onset – therefore not lending itself to a singular genetic correction. This interview took place during the 2022 World Congress on Controversies in Neurology (CONy) meeting.
Synaptogenix –Chair of Scientific Advisory Board and Equity Nervgen—Scientific Advisory Board Neurotez- Equity