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AD/PD 2023 | The potential of calcineurin inhibitors in reducing the prevalence of dementia.

Jacqueline Silva, PhD Candidate, The University of Texas Medical Branch, Galveston, TX, explains the significance of calcineurin inhibitors (CNIs) in reducing the prevalence of dementia. Using electronic health records from a global research network, data was collected on patients who were treated with tacrolimus or cyclosporine. Although the use of either agent was associated with a reduction in the prevalence of dementia compared to an age-matched general population control, tacrolimus was more effective (18% risk reduction). Its superior effect could be attributed to its brain penetrance, as cyclosporin only has peripheral action. The efficacy of cyclosporin despite its non-brain penetrant nature demonstrates the value of peripheral action of CNIs. The drugs are both well established and are widely used for immunosuppression; therefore, approval for use in dementia prevention could be streamlined if proven effective. This interview took place at the AD/PD™ 2023 congress in Gothenburg, Sweden.

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