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AAIC 2022 | The prodromal phases of Alzheimer’s disease

Krista Lanctôt, PhD, University of Toronto, Toronto, ON, Canada, addresses how Alzheimer’s disease (AD) is starting to be identified much earlier on in its development and notes the benefits this has on patient quality of life. AD is now an umbrella term which includes the prodromal phases of the disease, which is largely due the advent of molecular biomarkers which can define people at risk much earlier in the disease process. The same applies to neuropsychiatric symptoms in AD, which is why the NPS-PIA have developed a checklist for the diagnosis of mild behavioral impairment (MBI). It is important that these neuropsychiatric symptoms are identified early, since it is known that they are key predictors of decreased quality of life. Therefore, even if intervention cannot change the trajectory of the disease, symptomatic treatments are still implicated so that patients have the best quality of life possible whilst their cognitive ability is still intact. This interview took place at the Alzheimer’s Association International Conference (AAIC) 2022 in San Diego, CA.


Dr Lanctôt gratefully acknowledges support from the Canadian Institutes of Health Research (PJ2-179753, PJT-183584), Pooler Charitable Fund, Canadian Consortium for Neurodegeneration in Aging (CNA 163902), Alzheimer’s Association Part the Cloud (PTCG-20-700751, PTC-18-543823), Weston Foundation (CT190002), and Alzheimer’s Drug Discovery Foundation (201808-2016354). Consultant or Advisory Board: BioXcel Therapeutics, Cerevel Therapeutics, Eisai Co., Ltd., ICG Pharma, Jazz Pharmaceuticals, Kondor Pharma, H LundbeckA/S, Merck Sharp Dohme, Novo Nordisk, Praxis Therapeutics, Sumitomo.