Transcranial pulse stimulation (TPS) is being investigated in Alzheimer’s disease based on its ability to modulate the brain in a precisely targeted manner. Different to existing ultrasound techniques, TPS uses single ultrashort shockwave pulses (3 µs) that avoids tissue warming and standing waves and enables spatially distinct stimulation that is not restricted to superficial layers. Lars Wojtecki, MD, PhD, Institute of Clinical Neuroscience and Medical Psychology, University Duesseldorf, Duesseldorf, Germany, comments on our current understanding of the mechanisms of action of TPS in AD. Based on current data, it remains unclear whether TPS exerts beneficial effects on cognitive function through direct neuromodulation or if these effects are secondary to non-specific changes in brain health, such as increased nitric oxide release, stimulation of mechanosensitive ion channels, nerve regeneration and increased blood flow. This interview took place at the AD/PD™ 2023 congress in Gothenburg, Sweden.
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