CTAD 2025 | The association between neurofibrillary tangles and fluid biomarkers of Alzheimer’s disease

Mahnaz Shekari, PhD, University of California, Berkeley, CA, discusses a study investigating the association between neurofibrillary tangles and fluid biomarkers of Alzheimer’s disease, using a cohort from the ALFA+ study. Dr Shekari highlights that the study found a strong association between tau PET signal and fluid biomarkers, and notes that plasma p-tau217 has good negative predictive value but not high positive predictive value in cognitively unimpaired individuals. This interview took place at the 18th Clinical Trials on Alzheimer’s Disease (CTAD) Conference in San Diego, CA.

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