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AD/PD 2026 | Leveraging omics for precision drug development in neurodegenerative diseases

Ornit Chiba-Falek, PhD, Duke University School of Medicine, Durham, NC, discusses the use of omics to increase precision in drug development for neurodegenerative diseases. Dr Chiba-Falek emphasizes the potential of molecular profiling and multi-omic approaches to accelerate the discovery of new treatments, enabling precision medicine approaches through gene-targeted therapy and accurate molecular biomarkers. This interview took place at the AD/PD™ 2026 International Conference on Alzheimer’s and Parkinson’s Diseases in Copenhagen, Denmark.

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Transcript

Alzheimer’s and Alzheimer-related dementia represent a group of heterogeneous and multifactorial diseases with several molecular subtypes. Therefore, there is no single silver bullet to fight this group of diseases. For the next generation of Alzheimer-related dementia drug development pipeline, we need to shift the paradigm. Advances in molecular profiling and multi-omic approaches could accelerate the next generation of AD and related dementia drug discovery...

Alzheimer’s and Alzheimer-related dementia represent a group of heterogeneous and multifactorial diseases with several molecular subtypes. Therefore, there is no single silver bullet to fight this group of diseases. For the next generation of Alzheimer-related dementia drug development pipeline, we need to shift the paradigm. Advances in molecular profiling and multi-omic approaches could accelerate the next generation of AD and related dementia drug discovery. And this is going to be where biology meets precision medicine. We can leverage omics discovery to amplify the next generation of drug discovery. And this will come from gene-targeted therapy and accurate molecular biomarkers that will enable precision medicine approaches. I invite the audience of this video interview to watch our podcast series, Empowering Proteomics and Transcriptomics in Alzheimer’s Drug Discovery, where we have in-depth conversations about various aspects on these topics, including promises and challenges along the road.

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Disclosures

Dr Chiba-Falek is a coinventor of the related IP. Duke University filed patent applications for the technology developed in this study. Dr Chiba-Falek is a cofounder at CLAIRIgene.