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AAIC 2022 | Role of ancestry in the predictivity of genetic data

Brian Kunkle, PhD, MPH, University of Miami Miller School of Medicine, Miami, FL, notes the value of diversifying genetic research for risk prediction in the Alzheimer’s disease space. Studies conducted as part of the Alzheimer’s Disease Sequencing Project (ADSP) have shown that using genetic data from individuals with Hispanic ancestry/ethnicity to generate polygenic risk scores better predicts risk in that population, compared to when data from European populations is used. In this way, it is important to continue to characterize the genetic architecture of Alzheimer’s disease across diverse ancestral populations to get the most valuable, representative findings for people across the globe. This interview took place at the Alzheimer’s Association International Conference (AAIC) 2022 in San Diego, CA.