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ESOC 2022 | Visualizing blood-brain barrier dysfunction as an early marker of neurodegeneration

Axel Montagne, PhD, UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK, talks on the use of advanced imaging to study the blood-brain barrier (BBB) in health and disease states. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) produces sequential images during administration of a contrast agent, reflecting the temporal enhancement pattern of a tissue. In this way, subtle leakage of the BBB can be visualized. This technique has shown that BBB dysfunction can be imaged years before the onset of cognitive decline in patients. Notably, APOE4 carriers show greater tracer leakage in certain areas, including the hippocampus. Dr Montagne comments on the potential of BBB imaging as a predictive marker in dementia. This interview took place at the ESOC 2022 congress in Lyon, France.