Philip Tipton, MD, Mayo Clinic, Jacksonville, FL, discusses the use of deep brain stimulation (DBS) for the treatment of Alzheimer’s Disease (AD). Over 100 people have had bilateral DBS to stimulate the Papez memory circuit in Phase I and II clinical trials. The results vary, which experts believe is due to differences in age, disease, lead location, and stimulation parameters. An analysis of 46 patients with bilateral fornical DBS found that the majority of active contacts on DBS electrodes were within 2mm of both the Papez circuit and the bed nucleus of stria terminalis (BNST). Modeling techniques revealed that the most effective location for DBS is likely between the Papez circuit and BNST. This interview took place at the American Academy of Neurology Annual Meeting 2023 in Boston, MA.
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