Mourad Tayebi, PhD, Western Sydney University in Penrith, Australia, discusses his work towards the development of an ‘eye test’ for Alzheimer’s disease (AD), using nanobodies targeted towards retinal amyloid-beta (Aβ) oligomers. The team have developed nanobodies fused to near-infrared fluorescent proteins that are able to discriminate between APP/PS1 mice and control mice with high sensitivity and specificity. Looking ahead, Dr Tayebi is collaborating with a company to develop a miniature, portable OCT device able to easily detect the presence of retinal Aβ. This interview took place at the AD/PD™ 2023 congress in Gothenburg, Sweden.
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