So we’re still working also on the question on how different metabolites are changing before the onset of Alzheimer’s disease. And what we think is that in many patients, before they develop the disease they have a change in their gut microbiome. And this may be partly driven by the genes causing Alzheimer’s disease, but it may also partly driven by lifestyle of the people: what they eat, how much they do exercise...
So we’re still working also on the question on how different metabolites are changing before the onset of Alzheimer’s disease. And what we think is that in many patients, before they develop the disease they have a change in their gut microbiome. And this may be partly driven by the genes causing Alzheimer’s disease, but it may also partly driven by lifestyle of the people: what they eat, how much they do exercise. And what we’ve basically been finding now, very strong evidence that the guy microbiome is really determining the metabolite in your blood. And that may have a secondary effect on how the brain can perform, because the blood and the brain are of course, always communicating in the sense that nutrition goes into the brain, and the chemicals which are no longer needed are taken out. So what we’ve found is actually that the communication between the gut and the brain may be very important for people to maintain a healthy posture and healthy lifestyle. But also vice versa that the brain is steering the gut and telling it, well can you change a little bit more the absorption in the brain, so I have a little bit more fatty acid or bile acid that I can use to battle the disease.
