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ARUK 2022 | The role of metabolism in the development of Alzheimer’s disease

Cornelia van Duijn, PhD, Nuffield Department of Population Health, University of Oxford, Oxford, UK, discusses recent research into the role of metabolic disruption in the development of Alzheimer’s disease (AD). Two sets of metabolites, citrate and ketone bodies, were identified as good indicators of changes occurring before the development of AD, and both can be altered with diet or medication. If found to play a role in dementia pathogenesis, the next step for research in this area will be to translate these findings into effective interventional treatments to halt or prevent the development of disease. This interview took place at the Alzheimer’s Research UK Conference 2022 in Brighton, UK.


Cornelia van Dujin had preaccess from the Nightingale Health UK Biobank Initiative, but received no payment.