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AAIC 2026 | Guidance for the quantitative assessment of amyloid PET imaging

Alexis Moscoso, PhD, University of Gothenburg, Gothenburg, Sweden, shares guidance for the quantitative assessment of amyloid PET imaging. Dr Moscoso emphasizes that visual interpretation is mandatory and should be complemented by quantification in borderline cases. Dr Moscoso highlights the need for practitioners to follow established practices, including a specific methodology for visual assessment and the appropriate use of quantification as an additional metric to support visual interpretation. This interview took place at the 2026 Alzheimer’s Association International Conference (AAIC) in London, UK.

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Transcript

Yeah, this was basically more of an educational session, right? Because I basically summarized first the methodology for visually assessing amyloid scans with Vizamyl, right? So we must not forget that there is a specific methodology, a structured visual read method that needs to be applied in order to classify an amyloid scan as positive or negative. So I basically summarized the steps, how this method is performed, color scales, and so on...

Yeah, this was basically more of an educational session, right? Because I basically summarized first the methodology for visually assessing amyloid scans with Vizamyl, right? So we must not forget that there is a specific methodology, a structured visual read method that needs to be applied in order to classify an amyloid scan as positive or negative. So I basically summarized the steps, how this method is performed, color scales, and so on. Because sometimes some practitioners forget that amyloid PET scans need to be interpreted in a structured way by people with the appropriate training. So that was one of the core messages we wanted to transmit in this presentation. The second one was the amyloid scale, right? So basically now quantification is also approved, approved by the FDA and also by the EMA in Europe. But quantification needs to be understood as a complement or as an additional metric to support what we are seeing in the visual interpretation. So one of the key messages I wanted to give in this presentation is that visual interpretation is always necessary, it’s mandatory, right? And then you can complement your visual assessment with quantification in case that you are seeing a borderline case, you are not sure, right? And then quantification can help you to decide whether the scan is positive or negative, right? This is because, yeah, we’ve been aware of some sites that were relying only on quantification, rather than spending the time on visually assessing the scans. This is not appropriate. And, yeah, we wanted to emphasize here, basically, overall, the good, let’s say, the established practices to assess an amyloid PET scan with Vizamyl, which is always relying, first, on the visual interpretation, following the structured methodology described in the corresponding label. And second, clarify what’s the role of quantification. Quantification should never be performed in isolation. It’s always to complement or to help the visual read assessment.

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