Julia Neitzel, PhD, Erasmus University Medical Center, Rotterdam, Netherlands, shares the findings of her work assessing the association between 24-hour activity rhythms, sleep, and amyloid pathology. Participants in the prospective, population-based Rotterdam study were asked to wear activity watches for 7 days, in order to assess variability in 24-hour activity rhythms, sleep efficiency, sleep onset latency, total sleep time, and wake after sleep onset. Amyloid-PET was then performed on average 7.8 years later. It was demonstrated that a more fragmented activity rhythm was associated with higher amyloid-PET, particularly in APOE4 carriers. This association remained following the exclusion of participants likely to already be on the Alzheimer’s disease pathway (based on hippocampal volume and atrophy levels), suggesting fragmented activity rhythms may be a risk factor, rather than a result of amyloid pathology. This interview took place at the Alzheimer’s Association International Conference® (AAIC) 2023 in Amsterdam, Netherlands.
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