Post-mortem studies have often shown that individuals with no cognitive complaints during their lifetime can exhibit significant Alzheimer’s disease pathology. Although it remains unclear whether these individuals would remain clinically normal with longer survival, they appear to compensate for or delay the appearance of dementia symptoms. The reasoning for this cognitive resilience remains incompletely elucidated. Julia Neitzel, PhD, Erasmus University Medical Center, Rotterdam, Netherlands, comments on the need for further study of changes during the asymptomatic state, to shed light on potential protective or compensatory factors. This interview took place at the Alzheimer’s Association International Conference® (AAIC) 2023 in Amsterdam, Netherlands.
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