Emerging evidence suggests that the recently approved anti-amyloid therapies are most efficacious in amyloid β (Aβ)-positive individuals without a high tau burden. Lyduine Collij, PhD, BioFINDER group, Lund University, Lund, Sweden, shares her research looking into plasma biomarkers as prescreening tools to identify Aβ-positive patients without an advanced stage of tau pathology who are most likely to benefit from anti-amyloid immunotherapies. Over 900 individuals from the BioFINDER-2 cohort were included in the study. Numerous biomarkers were assessed for their ability to classify participants by Aβ and tau status, including p-tau181, p-tau217, p-tau231, GFAP, and NfL. Plasma p-tau217 was the most strongly associated with Aβ-positivity. Using a 2-cut-point procedure, individuals with a high certainty of Aβ-positivity or -negativity were separated from those with ambiguous plasma p-tau217 values, minimizing the need for confirmatory PET scans. When assessing tau load among Aβ-positive participants, p-tau217 was the best performing biomarker for identifying low-intermediate versus high tau-PET. In this way, plasma p-tau217 was shown to efficiently identify Aβ-positive individuals likely to have a low tau load according to tau-PET, minimizing the number of confirmatory Aβ- and tau-PET tests required.
For full study details: https://jamanetwork.com/journals/jamaneurology/article-abstract/2812432
This interview took place at the CTAD 2023 conference in Boston, MA.
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