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ARUK 2022 | The immunoregulatory role of the gut microbiome in Alzheimer’s disease

Edina Silajdzic, PhD, King’s College London, London, UK, talks on a study comparing the gut microbiome and the inflammatory profile in the blood of patients with Alzheimer’s disease (AD) compared to healthy participants. Blood and fecal samples from healthy participants and from patients with AD were analyzed. The blood from both groups was added to a cell-based assay. The study found that fewer cells in the assay which received blood from AD patients differentiated into neurons, compared with the assay using blood from healthy participants. The fecal samples from both groups were transplanted into rats. Rats transplanted with feces from AD patients had less neurogenesis and had cognitive problems associated with the hippocampus. This interview took place at the Alzheimer’s Research UK Conference 2022 in Brighton, UK.