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CTAD 2023 | EEG changes seen in Alzheimer’s disease

Willem de Haan, MD, PhD, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands, comments on the changes in EEG seen in patients with Alzheimer’s disease (AD). The archetypal EEG in AD shows a general diffuse slowing of brain activity. For instance, a consistent observation is the prominence of alpha waves (8-12 Hz) in healthy individuals, while a gradual slowing of this rhythm towards the theta range is typical in AD. Additionally, EEGs can reveal more advanced observations, including the loss of functional connectivity in individuals with AD. This interview took place at the Clinical Trials on Alzheimer’s Disease (CTAD) congress 2023 in Boston.

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Willem de Haan reports the following disclosures: Our EEG lab performs EEG analysis in pharmaceutical trials by Cognition Therapeutics, Vivoryon, Immunobrain, Treeway and CervoMed (for which I do not receive personal compensation).