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CTAD 2023 | Enhancing clinical trials: central EEG analysis for optimal research insights

Willem de Haan, MD, PhD, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands, comments on the implementation of EEG as a functional endpoint in Alzheimer’s disease (AD) clinical trials. His team have been running an EEG lab for central EEG analysis for large, multicenter, clinical trials for over a decade. For trials incorporating EEG as an outcome measure, the lab advises on how often to record EEGs, technical requirements, and provides manuals, instructions, and coaching to the clinical trial sites. Prior to the trial, participating sites are required to produce high-quality EEG data that meets specific standards. During the trial, resting-state EEGs are sent to the lab where they are quality checked and ideal segments are selected through experienced visual analysis. Once the EEG dataset is complete, a quantitative analysis is conducted using specialized software which measures various markers relevant to the study’s outcomes. This interview took place at the Clinical Trials on Alzheimer’s Disease (CTAD) congress 2023 in Boston.

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Willem de Haan reports the following disclosures: Our EEG lab performs EEG analysis in pharmaceutical trials by Cognition Therapeutics, Vivoryon, Immunobrain, Treeway and CervoMed (for which I do not receive personal compensation).