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BNA 2023 | The impact of neurovascular dysfunction in early-stage Alzheimer’s Disease

Silvia Anderle, PhD, University College London, focuses on understanding the role of neurovascular dysfunction in Alzheimer’s disease (AD). Her research sheds light on the significance of vascular dysfunction as an early sign of the disease, even preceding the development of cognitive symptoms. Vascular dysfunction is thought to play a crucial role in the pathogenesis of AD. One notable deficit is the increased stiffness of blood vessels, which impairs their ability to dilate and consequently reduces blood supply to neurons, compromising their functionality. Moreover, Dr Anderle highlights how vascular dysfunction can also result in increased permeability of blood vessels, leading to the breakdown of the blood-brain barrier. Exposure to toxic substances from leaky vessels, coupled with the insufficient oxygen and nutrients reaching neurons, contributes to their impairment and dysfunction. Dr Anderle’s research emphasizes the critical role that vascular dysfunction plays in AD and highlights the need for interventions that address this aspect of the disease. This interview took place at The BNA 2023 International Festival of Neuroscience in Brighton, UK.

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