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AAN 2025 | Early recognition and specialist referral critical for Alzheimer’s intervention

Bradford Dickerson, MD, Massachusetts General Hospital, Boston, MA, discusses critical clinical signs that should prompt primary care providers to refer an individual for further evaluation for Alzheimer’s disease. He mentions problems such as word-finding difficulty, memory loss, or difficulty with daily activities, which should prompt a problem-focused visit to evaluate the patient’s condition. Prof. Dickerson suggests involving the patient’s spouse or someone familiar with their condition to gain a better understanding, and considering referrals to specialists such as neuropsychologists or geriatric psychiatrists for a comprehensive evaluation. This approach is crucial, as early intervention with disease-modifying therapies for Alzheimer’s disease is most effective. This interview took place at the 77th American Academy of Neurology (AAN) Annual Meeting in San Diego, CA.

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Transcript

When a primary care provider hears that a patient is experiencing word-finding difficulty or memory loss or difficulty getting things done, they really should set up a problem-focused visit to evaluate that, not just attribute it to stress or age or sleep disturbance. Set it up as a problem and evaluate it in a specific way, ideally getting the perspective of the spouse or someone else who knows the person well...

When a primary care provider hears that a patient is experiencing word-finding difficulty or memory loss or difficulty getting things done, they really should set up a problem-focused visit to evaluate that, not just attribute it to stress or age or sleep disturbance. Set it up as a problem and evaluate it in a specific way, ideally getting the perspective of the spouse or someone else who knows the person well. And if there are questions, which there often are, consider a referral to a neuropsychologist for a neuropsychological assessment or to a specialist neurologist or geriatric psychiatrist for a specialty evaluation. At this point in time, we don’t think that the new disease-modifying therapies for Alzheimer’s disease are possible for primary care clinicians to administer safely and effectively. So those are really subspecialty care treatment options that I think are motivating a lot of people to get those evaluations done because they’re most effective at an early stage.

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