In the head-to-head study, we investigated the associations between plasma p-tau and both tau-PET tracers because we know that plasma p-tau217 associates with tau-PET. However, no study compared the associations in the same set of individuals to see if we have a difference between the tracers and the associations with plasma p-tau. And what we found is that with the association of plasma p-tau with MK in early tau regions was stronger than with flortaucipir...
In the head-to-head study, we investigated the associations between plasma p-tau and both tau-PET tracers because we know that plasma p-tau217 associates with tau-PET. However, no study compared the associations in the same set of individuals to see if we have a difference between the tracers and the associations with plasma p-tau. And what we found is that with the association of plasma p-tau with MK in early tau regions was stronger than with flortaucipir. Also, MK, plasma p-tau, which is 217, detects tau pathology when we look with MK at early concentrations, then flortaucipir. When we look at the cognitively impaired individuals with more late tau pathology, both tracers perform similarly. So the main difference would be in early tau pathology, where the associations with plasma p-tau and MK were strong.
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