Irene Cumplido-Mayoral, PhD Candidate, Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain, gives an insight to the use of biomarkers to predict brain aging. Age is one of the main risk factors for AD and many other neurodegenerative diseases, therefore a better understanding of the mechanistic links between neurodegeneration and normal brain aging is of interest to researchers. This is the rationale for studying brain aging using MRI measurements. By using these methods, researchers are trying to develop biomarkers that can detect the risk of different neurodegenerative diseases on an individual basis, based on how their predicted brain age compares to their chronological age. It is hoped these markers could inform therapeutic development of agents targeted against brain aging. This interview took place at the Clinical Trials on Alzheimer’s Disease congress 2022 in San Francisco.