AD/PD 2024 | Interactions between Aβ and tau proteins in Alzheimer’s disease

Gaël Chételat, PhD, HDR, Inserm, Université de Caen-Normandie, Caen, France, discusses the interaction of amyloid beta (Aβ) and tau proteins in Alzheimer’s disease. Aβ has not been shown to be responsible for the specificity of the topography of tau, but does interact with tau to promote and accelerate its propagation. Dr Chételat highlights the importance of conducting more longitudinal studies, taking into account different possible predictors to model the propagation of different pathologies. Considering the individual characteristics of the epicentres of protein spread may also help to be more precise in predicting topography of propagation. This interview took place at the AD/PD™ 2024 congress in Lisbon, Portugal.

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