This World Alzheimer’s Day special features Suzanne Schindler, MD, PhD, Washington University in St. Louis School of Medicine, St. Louis, MO, who discusses the early diagnosis of Alzheimer’s disease. Prof. Schindler speaks about barriers to early diagnosis, how primary care and specialists can work together to reduce diagnostic delays, the role of blood-based biomarkers, and the importance of identifying candidates for amyloid-targeting therapies early.