Dr Katerina Akassoglou, PhD, from the University of California San Francisco, San Francisco, CA, discusses new imaging technology developed by her lab to determine the role of the neurovascular interface in neurodegenerative disease. This technology was used to detect cerebrovascular alterations and fibrin deposits in neurodegenerative diseases, then observe their consequences for microglial cells. The lab combines high-resolution imaging at the cellular level with functional imaging to determine how microglia dynamically respond to cerebral blood leaks and fibrin deposits in the brain. This multimodal imaging approach provides a three-dimensional image of the brain’s structure, helping to identify the spatial and temporal localization of blood leaks in relation to microglia. Recorded at the Alzheimer’s Association International Conference (AAIC) 2023 held in Amsterdam, Netherlands.
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K.A. is the scientific founder, advisor and shareholder of Therini Bio, Inc. Her interests are managed by Gladstone Institutes according to its conflict of interest policy.