AD/PD 2023 | Potential role of microglia in amyloid plaque formation and spread

Santiago Solé-Domènech, PhD, and Rudy Gregory Jacquet, PhD Candidate, Weill Cornell Medicine, New York, NY, comment on our current understanding of the formation of extracellular amyloid beta (Aβ) deposits in Alzheimer’s disease (AD). It is generally thought that Aβ is secreted into the extracellular space or released from dying neurons, where it aggregates to form amyloid plaques. Evidence supports the occurrence of intraneuronal Aβ accumulation preceding amyloid pathology, and thus some believe that plaques may originate intraneuronally. Dr Solé-Domènech highlights the potential role of microglia in this process, via the spread of Aβ seeds. This interview took place at the AD/PD™ 2023 congress in Gothenburg, Sweden.

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