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AAIC 2023 | Genes differentially associated with Alzheimer’s disease based on sex and APOE status

Michael E. Belloy, PhD, Stanford University, Stanford, CA, discusses his recent genome-wide association study (GWAS), investigating how biological sex and APOE4 status influence genetic risk in late-onset Alzheimer’s disease (AD). In this study, large scale genetic analysis was undertaken on publicly available data from individuals with an AD diagnosis or familial history of AD. GWAS was utilized to identify genetic risk loci differentially associated with AD risk across APOE4 and/or sex, and functional follow-up analyses assessed potential relevance to AD based on mechanistic links or QTL co-localization. This research overall hopes to uncover genes which may be therapeutic targets. This interview took place at the Alzheimer’s Association International Conference® (AAIC) 2023 in Amsterdam, Netherlands.

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