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AAIC 2023 | Age-related variations in Alzheimer’s disease genetic risk associations

Many genetic risk factors associated with Alzheimer’s disease seem to have age-related effects, most prominent of which is APOE4. Dr Michael E. Belloy, PhD, from Stanford University, CA, speaks to us about the implications of these associations for at-risk individuals. For example, APOE4 appears to be most influential between the ages of 60 and 80 years old, with risk decreasing after the age of 80. This relationship between risk loci and age could provide insight into the choice of therapeutics used in individuals and how they might be developed in the future. Recorded at the Alzheimer’s Association International Conference (AAIC)® 2023 held in Amsterdam, Netherlands.

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