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CTAD 2022 | Diabetes-associated cognitive dysfunction

Florin Despa, PhD, University of Kentucky, Lexington, KY, shares an overview of the potential mechanisms involved in diabetes-associated cognitive dysfunction. It has been shown that the hypersecretion of pancreatic amylin seen in type 2 diabetes causes deposition of amylin in the cerebral microvasculature, leading to impaired transportation of oxygen, nutrients, and waste. Studies have also identified a glial response associated with cerebral amylin deposition, with the resultant neuroinflammation proposed to contribute to impaired cognitive function. This interview took place at the Clinical Trials on Alzheimer’s Disease congress 2022 in San Francisco.

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