Developments in our understanding of the role of mitophagy in dementia are fairly recent; here, Helene Plun-Favreau, PhD, from University College London, London, UK, discusses the correlation between a decline in autophagy or mitophagy and the progression of dementia and other age-related neurodegenerative diseases. She also offers her thoughts on the current search for novel treatments, explaining how finding a cure for one neurodegenerative disease may quickly lead to advancements in other related diseases. This video was recorded at the Alzheimer’s Research UK (ARUK) Conference 2018, held in London, UK.