Cell models are crucial for the study of neurodegenerative diseases; improved models greatly enhance the findings and quality of research. Speaking from the Alzheimer’s Research UK Conference 2018, held in London, UK, Nigel Hooper, PhD, of the University of Manchester, Manchester, UK, discusses his lab’s work on the creation of 3D culture models for the study of dementia. Prof. Hooper highlights the importance of cell-cell interactions in our understanding of the disease, which this model will help to mimic.