Laura Santambrogio, MD, PhD, Weill Cornell Medicine, New York, NY, describes the function of the lymphatic system. Firstly, it plays a vital role in fluid volume control in maintaining organ homeostasis. Secondly, it acts as a drainage system, which is critical to ensure the removal of metabolic and catabolic products in every organ. Finally, it is involved in immunosurveillance: immune cells, vesicle exosomes, and soluble protein peptides transported to the draining lymph nodes, which will interact with the immune system to analyze the function of that particular organ. This interview took place at the AD/PD™ 2022 International Conference on Alzheimer’s and Parkinson’s Diseases hosted in Barcelona, Spain.