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AAIC 2023 | Molecular processes driving psychosis in Alzheimer’s disease

Byron Creese, PhD, University of Exeter Medical School, Exeter, UK, shares his findings of a possible genetic influence underlying psychosis in Alzheimer’s Disease (AD). Psychotic symptoms, such as delusions and hallucinations, frequently occur in AD, affecting around 40-50% of AD patients. Research conducted by Dr Creese and his team assessed the molecular processes driving psychosis in AD, using a multi-omics approach. Significant differences in gene expression, DNA methylation, and non-coding RNAs were noted between patients with AD with versus without psychosis. Further research is still required to comprehend the molecular mechanisms at play in AD that overlap or differ from psychiatric disorders. This interview took place at the Alzheimer’s Association International Conference® (AAIC) 2023 in Amsterdam, Netherlands.

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