Oscar López, MD, FAAN, University of Pittsburgh, Pittsburgh, PA, explains the basics of mild cognitive impairment (MCI) and discusses the differences between MCI and dementia. MCI is defined by deficits in memory that do not significantly impact daily functioning and can precede the development of dementia, particularly Alzheimer’s disease (AD). Usually, patients with MCI have minimal to mild memory problems. Unlike AD, where cognitive abilities gradually decline and affect the patients’ ability to live independently, patients with MCI can perform their usual activities successfully. This interview took place at the American Academy of Neurology 2022 Congress in Seattle, WA.