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BNA 2023 | Impact of APOE4 on cellular function in astrocytes and microglia

Julia TCW, PhD, Boston University, Chobanian & Avedisian School of Medicine, Boston, MA, discusses her work looking at the impact of APOE4 expression on human brain cellular function. Brain cells derived from human post-mortem brain samples and human induced pluripotent stem cells were studied. Transcriptomic analyses demonstrated APOE4-driven cholesterol synthesis dysregulation in astrocytes and microglia, aligning with the known changes in lipid metabolism reported as a hallmark of Alzheimer’s disease pathophysiology. Matrisome dysregulation was also noted, associated with increased chemotaxis, inflammation, and lipid biosysnthesis. In this way, APOE4 acts on Alzheimer’s disease risk in microglia and astrocytes via cell autonomous and non-autonomous mechanisms. This interview took place at The BNA 2023 International Festival of Neuroscience in Brighton, UK.

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To contact Prof. TCW: [email protected], [email protected]