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AAIC 2022 | What is the relationship between COVID-19 and Alzheimer’s disease?

Carlos Cruchaga, PhD, Washington University School of Medicine, St Louis, MO, discusses the links between COVID-19 and Alzheimer’s disease (AD). There are many recent studies suggesting that some symptoms of COVID-19, which can include memory and cognition changes, are similar to those of AD. Moreover, studies have shown that COVID-19 infection can affect known AD biomarkers. Therefore, having more information on COVID-19 is extremely important to informing AD research and could help to clarify their relationship moving forward. The similarities between COVID-19 symptoms and AD suggests that they potentially have similar downstream pathways, and this could affect how new targets and therapies for AD are identified. Hence, the Alzheimer’s Disease Sequencing Project (ADSP) are particularly interested in understanding the overlap between COVID-19 and AD. This interview took place at the Alzheimer’s Association International Conference (AAIC) 2022 in San Diego, CA.


CC has received research support from: Biogen, EISAI, Alector and Parabon. The funders of the study had no role in the collection, analysis, or interpretation of data; in the writing of the report; or in the decision to submit the paper for publication. CC is a member of the advisory board of Vivid genetics, Halia Therapeutics and ADx Healthcare.