Costantino Iadecola, MD, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, explains how midlife vascular risk factors such as hypertension, obesity, and diabetes can act as a precursor and predict the risk of Alzheimer’s disease later on in life. Therefore, the clinical risk score for cardiovascular disease can also predict the risk of dementia. This interview was recorded during an online conference with The Video Journal of Dementia (VJDementia).