I utilized ARIC-NCS study which stands for atherosclerosis risk in communities and neurocognitive study. That is a very important study for vascular risk factors and nowadays there is a close relationship between heart disease and brain disease. And we are focusing on the neurocognitive function from ARIC data. The ARIC-NCS cohort participants have MRI scans, including diffusion MRI...
I utilized ARIC-NCS study which stands for atherosclerosis risk in communities and neurocognitive study. That is a very important study for vascular risk factors and nowadays there is a close relationship between heart disease and brain disease. And we are focusing on the neurocognitive function from ARIC data. The ARIC-NCS cohort participants have MRI scans, including diffusion MRI. We are analyzing diffusion tensor imaging, which visualizes the microstructure of the white matter. And white matter dysfunction is closely related to vascular risk factors, so we are further investigating. There is the most specific region of the white matter hyper-intensity region. I mean, around the hippocampus or frontal lobe lesion is closely related to cognitive dysfunctions. In the next step, beyond the diffusion tensor imaging, we are focusing on the DTI tractography, which visualizes the microstructure of fibers. And we focus on the perforant path fibers, which originate from the entorhinal layer 2 to the dentate gyrus of the hippocampus. It’s very important for memory creation, like a puppet circuit. So if we can use a new biomarker for memory creation, as a perforant path fiber number count. It’s a very highly promising neuroimaging biomarker with fluid biomarkers. So actually we have multiple external cohorts such as ADNI data and ABLE data. So we have internal analysis using ARIC and we need to extend our analysis for external validation using ADNI or ABLE.
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