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AAIC 2018 | LMNA dysfunction and Alzheimer’s disease

Dysfunction of the LMNA pathway, which is associated with nuclear membrane formation, has been identified in Alzheimer’s disease. Here, Celeste Karch, PhD, of Washington University in St. Louis, St. Louis, WA, discusses how this leads to cognitive decline in Alzheimer’s. Oxidative stress, protein homeostasis alterations, and mitochondrial defects are all associated with LMNA malfunction. Dr Karch explains how restoration of LMNA function might lead to more effective treatment of Alzheimer’s disease. This interview took place at the Alzheimer’s Association International Conference (AAIC) 2018, held in Chicago, IL.