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AAIC 2018 | Alzheimer’s and progeria: the LMNA pathway

Mutations in the LMNA gene, which mediates pathways associated with nuclear membrane formation, can result in a variety of diseases, including progeria. In this video, recorded at the Alzheimer’s Association International Conference (AAIC) 2018, held in Chicago, IL, Celeste Karch, PhD, of Washington University in St. Louis, St. Louis, WA, discusses the pathological similarities between progeria and Alzheimer’s disease, including a wrinkled nuclear phenotype. While LMNA mutations associated with progeria were not found in Alzheimer’s patients, there were changes in enzymes and substrates related to the LMNA pathway, which suggested a similar pathological effect. This insight into Alzheimer’s disease biology could facilitate future research to improve disease management and treatment.