Prof. Todd E. Golde, MD, PhD, Emory University, Atlanta, GA, speaks about new analyses on immune activation states in mouse models of Alzheimer’s disease, which display the relationship between plaque burden and microglial activation. Some post-mortem brain samples in humans with heavy amyloid plaque burden but minimal cognitive impairment show no evidence for microglial activation. However, this is based on fewer specimens so broader study is needed to examine the relationship between amyloid and microglial activation across multiple regions of the brain. This study emphasizes the need for improved biomarkers for microglial activation in humans, to ensure that antibody treatments are having a significant effect. Recorded at the Alzheimer’s Association International Conference (AAIC)® 2023 held in Amsterdam, Netherlands.
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