Prof. Todd E. Golde, MD, PhD, from Emory University, Atlanta, GA, discusses the manipulation of the immune system to clear amyloid deposits found in Alzheimer’s disease, and the difficulties associated with finding an ideal level of immune system activation. Both activation and suppression of the immune response as part of immunotherapies can have negative side-effects in AD. Although increased activation has shown benefit to patients, over-activation of the immune system can result in amyloid-related imaging abnormalities (ARIA), which limits clinical use. Recorded at the Alzheimer’s Association International Conference (AAIC)® 2023 held in Amsterdam, Netherlands.
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