Lea Grinberg, MD, PhD, University of California, San Francisco, CA, discusses the concept of selective neuronal vulnerability in neurodegenerative diseases. Selective vulnerability incorporates the idea that not all neurons in the brain will respond uniformly in the instance of injury. While much work has been focused on addressing the cause of injury, not much emphasis has been given to addressing the selective vulnerability of neurons. Dr Grinberg considers the potential in increasing neuronal resistance to injury; there is a need to further understand how different neurons react to certain neurodegenerative injuries, allowing for the development of neuroprotective mechanisms. This interview was conducted during the 2022 World Congress on Controversies in Neurology (CONy) meeting.