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AAIC 2022 | What do we understand about the secretion of brain p-tau in AD?

Marc Suárez-Calvet, MD, PhD, Barcelonaβeta Brain Research Center (BBRC), Barcelona, Spain, shares insights on the molecular processing and secretion of brain phosphorylated-tau (p-tau). Interestingly, levels of some p-tau species in fluids, either cerebrospinal fluid or blood, increase earlier than tau PET and therefore, may reflect amyloid pathology better than the tau pathology. It is possible that a proportion of the p-tau is released as an active secretion in response to the amyloid pathology. Future research may need to reconsider where we classify p-tau biomarkers in the ATN classification. This interview took place at the Alzheimer’s Association International Conference (AAIC) 2022 in San Diego, CA.